Diastereoselective addition of grignard reagents to azetidine-23-dione: Synthesis of novel taxol analogues

Article abstract of DOI:10.1016/0040-4039(96)01420-7

Synthesis and cytotoxicity properties of novel C-2' analogues of paclitaxel are described. The analogues were synthesized using Holton's β-lactam approach to append the side chain on baccatin III. The key intermediate to the synthesis of novel analogues w