Bioorganic and Medicinal Chemistry Letters p. 2187 - 2192 (1996)
Update date:2022-08-03
Topics:
Schostarez, Heinrich J.
O'Sullivan, Theresa J.
Groppi, Vincent E.
Cipkus-Dubray, Loretta A.
Bioisosteric substitution of the cyanoguanidine group found in pinacidil (1) with a 3,4-diamino-1,2,5-thiadiazole-1-oxide moiety and replacement of the 4-aminopyridine group with a 3,5-dichlorophenyl group has resulted in a new structural class of potassium channel opener (PCO).
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