Cyanoguanidine bioisosteres in potassium channel openers: Evaluation of 3,4-disubstituted-1,2,5-thiadiazole-1-oxides

DOI: 10.1016/0960-894X(96)00397-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2187 - 2192 (1996)

Update date:2022-08-03

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Authors:

Schostarez, Heinrich J.

O'Sullivan, Theresa J.

Groppi, Vincent E.

Cipkus-Dubray, Loretta A.

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Article abstract of DOI:10.1016/0960-894X(96)00397-6

Bioisosteric substitution of the cyanoguanidine group found in pinacidil (1) with a 3,4-diamino-1,2,5-thiadiazole-1-oxide moiety and replacement of the 4-aminopyridine group with a 3,5-dichlorophenyl group has resulted in a new structural class of potassium channel opener (PCO).

Full text of DOI:10.1016/0960-894X(96)00397-6

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