Journal of the Chemical Society. Perkin transactions I p. 2257 - 2260 (1996)
Update date:2022-08-03
Topics:
Bridson, Peter K.
Huang, Huan
Lin, Xiaoyan
The preparation of 6-amino-1,8-dihydroimidazo[4,5-e][1,3]diazepin-4(5H)-one (15), an analogue of guanine which has a seven-membered ring in place of the usual six-membered ring, is described. Cyclization to form the aminodiazepine ring involves reaction of amide and isothiourea groups in a suitably substituted imidazole precursor. The method is also shown to be applicable to the synthesis of an acyclonucleoside derivative (20).
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