Electrophilic sulfenylation in a stereocontrolled synthesis of protected (2R,3R)-3-mercaptoaspartic acid from L-aspartic acid

DOI: 10.1016/0040-4020(96)00765-X

Source and publish data:

Tetrahedron p. 12839 - 12852 (1996)

Update date:2022-08-05

Topics:

Authors:

Shibata, Norio

Baldwin, Jack E.

Jacobs, Adam

Wood, Mark E.

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Article abstract of DOI:10.1016/0040-4020(96)00765-X

A novel electrophilic sulfenylating agent, (2,4-dimethoxybenzylthio)-4-methylphenyl sulfonate (13) was developed to give thiols bearing an acid labile protecting group. This was subsequently used to prepare in a stereocontrolled manner, a protected form of (2R,3R)-3-mercaptoaspartic acid which was incorporated into a tripeptide.

Full text of DOI:10.1016/0040-4020(96)00765-X

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