EPC-synthesis of functionalised amides via chiral β-nitrogenated organolithium compounds

Article abstract of DOI:10.1016/0957-4166(96)00382-5

The deprotonation of chiral chloroamides or carbamates 1, 4, 7, 10, 13 and 16 with n-butyllithium followed by in situ lithiation with lithium naphthalenide, both at -78°C in THF, leads to the formation of the corresponding chiral dianionic intermediates,