Synthesis of Bis-γ-Butyrolactones Containing Conformationally Constrained (S)- and (R)-Diacylglycerol Structures

Article abstract of DOI:10.1016/0968-0896(96)00116-2

The synthesis of two sets of rigid diacylglycerol (DAG) analogues with either the (S)-DAG or (R)-DAG enantiomer embedded into a bis-γ-butyrolactone template was accomplished stereoselectively from di-O-isopropylidene-α-D-apiose.The key step in both synthe