MOM-protected 3-hydroxy-5-phenyl-isoxazole: Regioselective preparation and synthetic application

DOI: 10.1016/0040-4039(96)01547-X

Source and publish data:

Tetrahedron Letters p. 6857 - 6860 (1996)

Update date:2022-09-26

Topics:

Authors:

Alzeer, Jawad

Nock, Nadine

Wassner, Guy

Masciadri, Raffaello

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Article abstract of DOI:10.1016/0040-4039(96)01547-X

Highly regioselective (> 90%) MOM-protection of 3-hydroxy-5-phenyl-isoxazole, followed by elaboration in 4-position via directed ortho-metalation and mild deprotection with cold methanolic HCl provided ready access to a series of zwitterionic isoxazole derivatives.

Full text of DOI:10.1016/0040-4039(96)01547-X

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