Journal of Heterocyclic Chemistry p. 1227 - 1232 (1996)
Update date:2022-08-03
Topics:
Jurd
Morpholino Mannich bases of types 5, 12 react with tetronic acid in aqueous acetic acid to yield uncyclized lactones of types 7, 13. Acetylation and methylation of these products yields monoacetylmonomethyl derivatives which can then be cyclized in alkali to give unsaturated lactones of types 8, 16 and saturated lactones 9b, 15. The hydroxylactone 9a can be synthesized directly by reaction of 3,4,5-trimethoxybenzaldehyde with sesamol and tetronic acid in methanol. With few exceptions the lactones of type 8 and 16 have proven to be active inhibitors of tumor growth in the National Cancer Institute in vitro screening program against 60 diverse human cancer cell lines. The lactone 8 is particularly potent, inhibiting in vitro growth of some cancers at concentrations as low as 10-6-10-7 moles/l.
View MoreMollt Biochem Co., Ltd(expird)
Contact:+86-21-38682181
Address:shanghai ,china
Jiangsu Dacheng Pharmaceutical and Chemical Co.,Ltd
Contact:+86-0517-87036900
Address:Chuzhou Chemical park, Huai'an, Jiangsu Province
Jiangsu Fengshan Group Co., Ltd.
Contact:86-25-86558671
Address:1903,Central International Mansion 105-6 North Zhongshan Road, Nanjing, China
Wuhan Benjamin Pharmaceutical Chemical Co.,Ltd
Contact:86-27-52341789
Address:Room 1518 B suite, optical valley time square, No 111 Guanshan Road, Hongshan District,Wuhan,Hubei Province,China.
Chongqing Rong&Quan Pharmaceutical Technology Co. , Ltd.
Contact:86-023-65268721
Address:No. 7, Manshanhong Village, Pingdingshan, Shapingba District, Chongqing Province, China
Doi:10.1021/ja9607300
(1996)Doi:10.1021/jm960401i
(1996)Doi:10.1021/ja00237a027
(1987)Doi:10.1016/0022-328X(90)85055-4
(1990)Doi:10.1016/j.jorganchem.2003.09.020
(2003)Doi:10.1021/jm960349q
(1996)