Aryl H-phosphonates. 8. Simple and efficient method for the preparation of nucleoside B-phosphonothioate monoesters

Article abstract of DOI:10.1016/S0040-4039(99)00617-6

An efficient method for the preparation of nucleoside 3'-H- phosphonothioate monoesters was developed. It consists of phosphonylation of suitably protected nucleosides with diphenyl H-phosphonate to produce nucleoside phenyl H-phosphonates, followed by th