Chemical and Pharmaceutical Bulletin p. 871 - 873 (1996)
Update date:2022-08-03
Topics:
Okada
Wang
Yamamoto
Mu
N(π)-1-adamantyloixymethylhistidine, His(N(π)-1-Adom) was prepared, and the properties of the 1-adom group were examined. 1-Adom group can be easily removed by TFA; it is stable to 20% piperidine/DMF and 1N NaOH. His(N(π+)- 1-Adom) derivatives can suppress recemization during coupling reaction. TRH was synthesized using His(N(π)-1Adom), successfully.
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Doi:10.1002/ardp.200400869
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(1972)Doi:10.1021/jo00975a028
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(2003)
