Development of a new N(π)-protecting group for histidine, N(π)-1- adamantyloxymethylhistidine

Article abstract of DOI:10.1248/cpb.44.871

N(π)-1-adamantyloixymethylhistidine, His(N(π)-1-Adom) was prepared, and the properties of the 1-adom group were examined. 1-Adom group can be easily removed by TFA; it is stable to 20% piperidine/DMF and 1N NaOH. His(N(π+)- 1-Adom) derivatives can suppress recemization during coupling reaction. TRH was synthesized using His(N(π)-1Adom), successfully.

Full text of DOI:10.1248/cpb.44.871

NII-Electronic Library Service

NII-Electronic Library Service

NII-Electronic Library Service