Rapid synthesis of an advanced functionalized monocyclofarnesyl intermediate using 1,2-dibromoethyl ethyl ether as a bromoacetaldehyde equivalent in the synthesis of furan-2(5H)-ones

DOI: 10.1055/s-1996-4378

Source and publish data:

Synthesis p. 1305 - 1308 (1996)

Update date:2022-07-31

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Authors:

Demnitz, F.W. Joachim

Raphael, Ralph A.

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Article abstract of DOI:10.1055/s-1996-4378

The lithium enolate of the ε-lactone 10 was reacted with 1,2-dibromoethyl ethyl ether to furnish 12, treatment of which with aqueous K₂CO₃ gave a highly functionalized sesquiterpene of the monocyclofarnesyl skeleton the 3-substituted furan-2(5H)-one 13a.

Full text of DOI:10.1055/s-1996-4378

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