Rapid synthesis of an advanced functionalized monocyclofarnesyl intermediate using 1,2-dibromoethyl ethyl ether as a bromoacetaldehyde equivalent in the synthesis of furan-2(5H)-ones

Article abstract of DOI:10.1055/s-1996-4378

The lithium enolate of the ε-lactone 10 was reacted with 1,2-dibromoethyl ethyl ether to furnish 12, treatment of which with aqueous K₂CO₃ gave a highly functionalized sesquiterpene of the monocyclofarnesyl skeleton the 3-substituted furan-2(5H)-one 13a.