Australian Journal of Chemistry p. 1577 - 1588 (1992)
Update date:2022-08-03
Topics:
Banwell, Martin G.
Peters, Steven C.
Greenwood, Richard J.
Mackay, Maureen F.
Hamel, Ernest
Lin, Chii M.
Commercially available (-)-colchicine (1) has been converted, via deacetylcolchiceine (4), into a mixture of 7-oxodeacetamidocolchicine (2) and 7-oxodeacetamidoisocolchicine (3).The X-ray structures and tubulin-binding properties of these title ketones are described.
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