Bioorganic and Medicinal Chemistry Letters p. 1261 - 1266 (1999)
Update date:2022-08-03
Topics:
Chen, Meng-Hsin
Pollard, Patrick P.
Patchett, Arthur A.
Cheng, Kang
Liente, Wei
Chan, Wanda W.-S.
Butler, Bridget
Jacks, Thomas M.
Smith, Roy G.
The synthesis and biological activities of a series of spiroheterocyclic growth hormone secretagogues are reported. Modification of the spiroindane part-structure of the prototypal secretagogue L-162,752 revealed that the spiroindane could be replaced with spirobenzodihydrothiophen derivatives to enhance not only in vitro potency but also oral activity. In this study non- aromatic D-2-amino-4-cyclohexylbutanoic analogs (8a-8d) were also identified to be active secretagogues.
View MoreHK Vast Medicinal Chemistry Int'l Group Limited(expird)
website:http://www.hkvast.com/
Contact:+86-15000309979
Address:NO.6,Lane 108,Qinzhou Road,Xuhui District,Shanghai
Contact:+86-0760-85282375
Address:zhongjing road,zhongshan torch hi-tech industrial development zone
A.M FOOD CHEMICAL CO., LIMITED
Contact:86-531-87100375
Address:20Floor,Bblock,1Building,pharma-valley,Jinan,China
Luzhou North Chemical Co., Ltd.
Contact:+86-830-2796784;+86-830-2796776
Address:Gaoba, Longmatan District, Luzhou, Sichuan Province
Contact:86 311 85902108 / 85902109
Address:room 1001-1005 ,huanghe Road ,shijiazhuang ,China
Doi:10.1039/c2ob26103k
(2012)Doi:10.1016/j.bmcl.2012.08.089
(2012)Doi:10.1002/aoc.5316
(2020)Doi:10.1016/S0040-4039(00)91610-1
(1992)Doi:10.1016/j.jphotochem.2012.06.013
(2012)Doi:10.1039/c2ce25480h
(2012)