Bioorganic and Medicinal Chemistry Letters p. 1261 - 1266 (1999)
Update date:2022-08-03
Topics:
Chen, Meng-Hsin
Pollard, Patrick P.
Patchett, Arthur A.
Cheng, Kang
Liente, Wei
Chan, Wanda W.-S.
Butler, Bridget
Jacks, Thomas M.
Smith, Roy G.
The synthesis and biological activities of a series of spiroheterocyclic growth hormone secretagogues are reported. Modification of the spiroindane part-structure of the prototypal secretagogue L-162,752 revealed that the spiroindane could be replaced with spirobenzodihydrothiophen derivatives to enhance not only in vitro potency but also oral activity. In this study non- aromatic D-2-amino-4-cyclohexylbutanoic analogs (8a-8d) were also identified to be active secretagogues.
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