A synthesis of (2R,4'R,8'R)-α-tocopherol (vitamin E) side chain

DOI: 10.1248/cpb.44.2153

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2153 - 2156 (1996)

Update date:2022-08-03

Topics: Molecular structure Column chromatography Reagents Catalyst Stereoselective synthesis Chemical reactions Purification Chirality Side chain

Authors:

Chen, Cheng Yu

Nagumo, Shinji

Akita, Hiroyuki

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Article abstract of DOI:10.1248/cpb.44.2153

Optically pore (3R,7R)-3,7,11-trimethyldodecan-1-ol (16), corresponding to the α-tocopherol side chain, was synthesized by the coupling reaction of a chiral isoprene unit (3S)-9 derived from an enzymatically hydrolyzed product (2S,3S)-2 and a ten-carbon alkylating reagent (R)-13 derived from (R)-(+)-pulegone.

Full text of DOI:10.1248/cpb.44.2153

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Product name:Butanoic acid, 3-methyl-4-(phenylsulfonyl)-, methyl ester, (3S)-

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