An efficient method for catalytic stereoselective synthesis of α-L-fucopyranosides

Article abstract of DOI:10.1246/cl.1996.1123

A new efficient method for the catalytic stereoselective synthesis of various α-L-fucosides by using an easily available and stable glycosyl donor, 2,3,4-tri-O-benzyl-L-fucopyranosyl methoxyacetate, is established. Also, trimethylsilyl trifluoroacetate and lithium perchlorate are found to be effective additives in the synthesis of Fucα1-3GlcNAc and Fucα1-4GlcNAc linkages.