Synthesis of novel ellipticine analogues and their inhibition of Moloney leukaemia reverse transcriptase

Article abstract of DOI:10.1016/S0960-894X(96)00521-5

Two new ellipticine analogues were synthetized as potential non nucleoside inhibitors of reverse transcriptase and were tested Moloney leukaemia virus reverse transcriptase in vitro. Both derivatives (9a,b) showed considerable inhibitory effect; ID₅₀ was found to be in the range of 2.8 to 4.5 x 10^-5 M.