Bioorganic and Medicinal Chemistry Letters p. 2831 - 2836 (1996)
Update date:2022-08-04
Topics:
Timari, Geza
Soos, Tibor
Hajos, Gyoergy
Messmer, Andras
Nacsa, Janos
Molnar, Jozsef
Two new ellipticine analogues were synthetized as potential non nucleoside inhibitors of reverse transcriptase and were tested Moloney leukaemia virus reverse transcriptase in vitro. Both derivatives (9a,b) showed considerable inhibitory effect; ID50 was found to be in the range of 2.8 to 4.5 x 10-5 M.
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