Tetrahedron Letters p. 9267 - 9270 (1996)
Update date:2022-08-03
Topics:
Stille, John R.
Ward, Jeffrey A.
Leffelman, Cindy
Sullivan, Kevin A.
5-Formyl salicylaldehyde was prepared by treatment of 4-hydroxybenzaldehyde with HMTA in TFA. Reaction of this dialdehyde with α-haloacetyl aryl compounds gave 2,5-disubstituted benzofurans, from which an Insulin Sensitivity Enhancer compound was prepared.
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