Tetrahedron Letters p. 6507 - 6510 (1996)
Update date:2022-08-02
Topics:
Persichetti, Rose A.
Lalonde, Jim J.
Govardhan, Chandrika P.
Khalaf, Nazer K.
Margolin, Alexey L.
Chiral resolutions of carboxylic acids (1-3) and alcohol (4) were carried out through esterification or transesterification in organic solvents using cross-linked enzyme crystals (CLEC) of Candida rugosa lipase (CRL). Comparison of these results with those of crude CRL reveal significant differences. As was seen in resolution through hydrolysis, a marked improvement in enantioselectivity is realized with the CLEC. Additionally, the stability afforded the enzyme in CLEC form leads to a higher activity in organic solvent.
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