Effective enantioselective approach to α-aminoalkylacrylic acid derivatives via a synthetic equivalent of an asymmetric Baylis-Hillman reaction: Application to the synthesis of two C-2′ hydroxymethyl analogues of docetaxel

DOI: 10.1039/P19960002869

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 2869 - 2872 (1996)

Update date:2022-08-04

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Authors:

Genisson, Yves

Massardier, Christine

Gautier-Luneau, Isabelle

Greene, Andrew E.

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Article abstract of DOI:10.1039/P19960002869

Two C-2′ hydroxymethyl analogues of docetaxel have been synthesized from 10-desacetyl baccatin III and enantiopure (3S)-3-(N-tert-butoxycarbonylamino)-2-methylene-3-phenylpropanoic acid; the latter was prepared via the use of a new method, which is discus

Full text of DOI:10.1039/P19960002869

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