Bioorganic and Medicinal Chemistry Letters p. 2827 - 2830 (1996)
Update date:2022-08-03
Topics:
Bertenshaw, Stephen R.
Talley, John J.
Rogier
Graneto, Matthew J.
Koboldt, Carol M.
Zhang, Yan
Benzothiopyranopyrazoles and benzopyranopyrazoles containing either a sulfone or sulfonamide moiety were synthesized and tested for COX-1 and COX-2 inhibition. This new class of COX-2 selective inhibitors possess antiinflammatory activity in vivo.
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