Conformationally restricted 1,5-diarylpyrazoles are selective COX-2 inhibitors

DOI: 10.1016/S0960-894X(96)00530-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2827 - 2830 (1996)

Update date:2022-08-03

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Authors:

Bertenshaw, Stephen R.

Talley, John J.

Rogier Rogier

Graneto, Matthew J.

Koboldt, Carol M.

Zhang, Yan

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Article abstract of DOI:10.1016/S0960-894X(96)00530-6

Benzothiopyranopyrazoles and benzopyranopyrazoles containing either a sulfone or sulfonamide moiety were synthesized and tested for COX-1 and COX-2 inhibition. This new class of COX-2 selective inhibitors possess antiinflammatory activity in vivo.

Full text of DOI:10.1016/S0960-894X(96)00530-6

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