Synthesis of a photoaffinity analogue of phosphatidylinositol 3,4-bisphosphate, an effector in the phosphoinositide 3-kinase signaling pathway

Article abstract of DOI:10.1016/S0040-4039(96)02117-X

A Ferrier rearrangement strategy starting from α-D-glucose gave a protected inositol, which after coupling to a chiral diacylglycerol phosphoramidite, provided a tritium-labeled, benzophenone-containing derivative of P-1-(O-aminopropyl) linked dipalmitoyl PtdIns(3,4)P₂. Copyright (C) 1996 Elsevier Science Ltd.