Bioorganic and Medicinal Chemistry Letters p. 3009 - 3012 (1996)
Update date:2022-08-03
Topics:
Tao, Ming
Bihovsky, Ron
Kauer, James C.
Dipeptidyl and tripeptidyl heterocycles designed to mimic peptide ketoamides and ketoacids were prepared and evaluated in vitro as inhibitors of human calpain I. Boc-Leu-Leu-imidazole (12) inhibited calpain I at low micromolar concentrations.
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