A New Reductive Acidolysis Final Deprotection Strategy in Solid Phase Peptide Synthesis. Use of a New Safety-Catch Linker

Article abstract of DOI:10.1016/S0040-4039(00)73241-2

A new reductive acidolysis final deprotection strategy in solid phase peptide synthesis was developed using a new safety-catch linker; this new strategy was based on a two-dimensional protection scheme employing acid-labile temporary and acid-stable but reductive acidolysiscleavable semipermanent protecting groups.