Synthesis and biological activity of β-glucuronyl carbamate-based prodrugs of paclitaxel as potential candidates for ADEPT

DOI: 10.1016/S0968-0896(96)00249-0

Source and publish data:

Bioorganic and Medicinal Chemistry p. 405 - 414 (1997)

Update date:2022-08-05

Topics:

Authors:

De Bont, Dries B. A.

Leenders, Ruben G. G.

Haisma, Hidde J.

Van Der Meulen-Muileman, Ida

Scheeren, Hans W.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0968-0896(96)00249-0

The syntheses of prodrugs of paclitaxel which can be used in ADEPT in order to target paclitaxel towards tumor cells, are described. The prodrugs 1 and 2a,b consist of a spacer molecule connected via a carbamate linkage to a β-glucuronic acid. The spacer

Full text of DOI:10.1016/S0968-0896(96)00249-0

Products guided by the article

Product name:2-(2-Allyloxycarbonyl-ethyl)-benzoic acid

Cas No:187840-93-3

R&D Labs maybe for 187840-93-3

Huayi Isotopes Co.

Contact:+ 86 512 52491118

Address:1 Fuyu Road, Haiyu TownChangshu, Jiangsu, China
Beijing eternalchem Co,. Ltd

Contact:+86-10-59484199

Address:No.58-A1026 Liangguan Street
Jining Shengrun Chemical Industry Co., Ltd.

Contact:+86-537-7121666 ,

Address:West Ring Road,Wenshang County Shandong Province
MENGNA

Contact:18698110882

Address:1303 No2 building,LuoMa Garden,YongAn Road,Hexi District,Tianjin city
Shanghai Puda Chemical Co.,Ltd

Contact:+86+571+56565965

Address:10F Haiyue Building,Danfeng Road,Binjiang District,Hangzhou,China

Relevant to this article

Synthesis of some thionocarbamates from O-isopropyl xanthate and amines using Pd/Ti-HMS-10 as catalyst in water

Doi:10.1007/s13738-016-0903-1
(2016)
Doi:10.1039/CT9140500040
(1914)
Role of substrate reactivity in the glutathione peroxidase (gpx) activity of selenocystine

Doi:10.1246/bcsj.20090348
(2010)
Doi:10.1246/bcsj.41.628
(1968)
Synthesis of 5,7-dihydroxy-6-methoxy-2-(2-hydroxy-4-methoxyphenyl)-4H-1-benzopyran- 4-one and reassignment of structure of tamaridone

Doi:10.1080/00397919708006071
(1997)
Regioselective oxidation of the hydroxyl group in polyhydroxylated triterpenes by the indirect anodic oxidation method

Doi:10.1248/cpb.45.570
(1997)

Article Doi