Organic Letters p. 1244 - 1248 (2020)
Update date:2022-08-04
Topics:
Zhang, Yuna
Shen, Shuna
Fang, Hua
Xu, Tao
Herein, we report a novel strategy toward galanthamine and lycoramine. The concise synthesis was enabled by a Rh-catalyzed gram-scale C-C activation for the tetracyclic carbon framework and a regioselective Pd-catalyzed C-H activation for double-bond introduction. An aqueous-phase Beckmann rearrangement was performed for nitrogen atom insertion. Galanthamine and lycoramine were completed in 11 and 10 steps, respectively.
View MoreContact:+86-371-55981030
Address:Room 1571, Macalline Soho, No.1, Shangdu Road, Zhengzhou, Henan
Contact:+36(21)2523420
Address:Head office: 1102 Budapest, SZENT LASZLO TER 24/B. 1/1., HUNGARY / CHINA
Shanghai Hongbang Medical Technology CO.,. Ltd
Contact:13671516988 /18917636693
Address:Room1, No67 Building, Yongde Road369, Wujing Town, Minhang Districy, Shanghai CIty, China.
Hubei Xinghuo Chemical Co., Ltd.,
Contact:13925817279 13907299441
Address:Xinghuo Fine Chemistry Industrial Park, Xiaochang County, Hubei Province, China
Changzhou naidechemical Co.Ltd
Contact:+86-519-82589807
Address:NO.25,Houyang street,Jintan,Changzhou City
Doi:10.1016/S0957-4166(96)00477-6
(1997)Doi:10.1021/acs.orglett.0c00625
(2020)Doi:10.1039/c39940001731
(1994)Doi:10.1016/S0040-4020(97)00087-2
(1997)Doi:10.1021/ja034222j
(2003)Doi:10.1002/ardp.19843170614
(1984)
