Tetrahedron Letters p. 7795 - 7798 (1995)
Update date:2022-07-29
Topics:
Liang, Xian
Kingston, David G. I.
Long, Byron H.
Fairchild, Craig A.
Johnston, Kathy A.
Oxidation of 2'-TBDMS-6α-hydroxy-7-epipaclitaxel (1) with lead tetraacetate furnished 2'-TBDMS-C-norpaclitaxel (2) and the C-seco compound 3.Deprotection of 2 with pyridinium hydrofluoride yielded C-norpaclitaxel (4).C-norpaclitaxel (4) is less effective at promoting the assembly of microtubules and less cytotoxic towards HCT116 cells than paclitaxel.
View MoreContact:0086-22-2822 1962 / 2822 1963
Address:B-808, No. 1, North-South Street, Hexi District,
Changsha Yihai Chemical Technology Co.,ltd
website:http://www.cs-yihai.com/
Contact:0731- 85620465
Address:Room 23005, unit 2, the northern building of Xiangsong international building , NO.259 Shaoshan Road , Changsha , Hunan, China.(mainland)
Zhejiang Peptites Biotech Co.,Ltd
website:http://www.peptide-china.com
Contact:86-575-83835818
Address:No.8,Hengyizhi Road,Sanjie Town,Shengzhou City,Zhejiang,China
Contact:86-21-50966856
Address:Building 5,300 Chuanzhan Road,Pudong New District,Shanghai
Shandong Xiangde Biotechnology Co., Ltd
Contact:+86 -15066639877
Address:Sanba street
Doi:10.1002/chem.19970030311
(1997)Doi:10.1021/ja962904j
(1997)Doi:10.1016/S0040-4039(98)00832-6
(1998)Doi:10.1016/j.tetlet.2009.09.082
(2009)Doi:10.1021/jm960592p
(1997)Doi:10.1021/ic961280f
(1997)
