Tetrahedron Letters p. 7795 - 7798 (1995)
Update date:2022-07-29
Topics:
Liang, Xian
Kingston, David G. I.
Long, Byron H.
Fairchild, Craig A.
Johnston, Kathy A.
Oxidation of 2'-TBDMS-6α-hydroxy-7-epipaclitaxel (1) with lead tetraacetate furnished 2'-TBDMS-C-norpaclitaxel (2) and the C-seco compound 3.Deprotection of 2 with pyridinium hydrofluoride yielded C-norpaclitaxel (4).C-norpaclitaxel (4) is less effective at promoting the assembly of microtubules and less cytotoxic towards HCT116 cells than paclitaxel.
View MoreLonzeal Pharmaceuticals Co., Ltd.
website:http://www.lonzeal.com
Contact:+86-13381011962
Address:RM 801, Yue MOMA, No. 26 Anningzhuang Rd. Haidian District, Beijing, China
Puyang Huicheng Electronic Material Co., Ltd
website:http://huichengchem.weba.testwebsite.cn/index_en.html
Contact:+86-393-8910800
Address:West Section Shengli Road, Puyang457000, China
Xiamen Huasing Chemicals Co.Ltd.
Contact:0086-592-6228397
Address:NO.24, Xinglin North 2nd Road,Jimei district
Yancheng Creator Chemical Co., Ltd
Contact:0086-515-88710008 88710068 88710858 88710868
Address:No.21 Renming Road, Longgang Town, Yandu County,Yancheng City
Jiangsu Zenji Pharmaceuticals LTD
Contact:+86-025-83172562; +1-224-888-1133(USA)
Address:No.5 Xinmofan Road
Doi:10.1002/chem.19970030311
(1997)Doi:10.1021/ja962904j
(1997)Doi:10.1016/S0040-4039(98)00832-6
(1998)Doi:10.1016/j.tetlet.2009.09.082
(2009)Doi:10.1021/jm960592p
(1997)Doi:10.1021/ic961280f
(1997)
