Tetrahedron Letters p. 7795 - 7798 (1995)
Update date:2022-07-29
Topics:
Liang, Xian
Kingston, David G. I.
Long, Byron H.
Fairchild, Craig A.
Johnston, Kathy A.
Oxidation of 2'-TBDMS-6α-hydroxy-7-epipaclitaxel (1) with lead tetraacetate furnished 2'-TBDMS-C-norpaclitaxel (2) and the C-seco compound 3.Deprotection of 2 with pyridinium hydrofluoride yielded C-norpaclitaxel (4).C-norpaclitaxel (4) is less effective at promoting the assembly of microtubules and less cytotoxic towards HCT116 cells than paclitaxel.
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