Bioorganic and Medicinal Chemistry Letters p. 623 - 628 (1997)
Update date:2022-07-30
Topics:
Pfaendler, Hans Rudolf
Medicus, Claus
As with the oxapenems, the 2-tert-butyl substituents substantially increased the hydrolytic stability of penems. The corresponding penems 1 and 2 were prepared and found to be extremely stable compounds. 2 showed good in vitro activity against gram-positive bacteria.
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