Bioorganic and Medicinal Chemistry Letters p. 1311 - 1316 (1997)
Update date:2022-07-30
Topics:
Toepfer, Alexander
Kretzschmar, Gerhard
Four piperidine carboxylic acid derivatives designed as mimetics of the sialyl Lewis X determinant were synthesized. Their inhibitory potency for selectin mediated cell adhesion was evaluated in cell culture assays, in vivo and in a reperfusion model. Compound 7 showed strong inhibition of leukocyte adhesion in rats and a powerful decrease of the incidence of arrhythmias in a reperfusion model in isolated rabbit hearts.
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