The synthesis of imidazole analogs of the kainoid family

Article abstract of DOI:10.1016/S0040-4020(97)00005-7

In an effort to mimic the anthelmintic and insecticidal activities of kainic 1 and domoic 2 acids with compounds of simpler structure and much easier accessibility, the highly functionalised imidazoIines 4, 27, and 28 were prepared. This involved a synthesis of suitably protected β-aminoglutamic acid derivatives as key intermediates, which were condensed with orthoesters and deprotected to yield the desired compounds.