Journal of Heterocyclic Chemistry p. 21 - 25 (1997)
Update date:2022-09-26
Topics:
Szabo, Monika
Koekoesi, Jozsef
Oerfi, Laszlo
Kovacs, Attila
Hermecz, Istvan
3H,7H-[1,4]Diazepino[3,4-b]quinazolone-3,7-diones 9, 11 were synthesized starting from 2-(1-bromoethyl)quinazolin-4(3H)-ones 3 and 17 via 2-[1-(4-methoxyphenylamino)ethyl]quinazolin-4(3H)-ones 4 and 18. Cyclization of 3-[2-(1-bromoethyl)-4-oxo-3,4-dihydroquinazolin-3-yl)propionic acid 14 by the action of triethylamine provided the first representative of the tricyclic 7H-[1,4]oxazepino[3,4-b]quinazoline-3,7-dione system, compound 15. The new tricyclic derivatives 9, 11 and 15 are characterized by uv, ir and 1H nmr spectroscopy.
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Doi:10.1021/jm960849j
(1997)Doi:10.1016/S0040-4020(01)00323-4
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(2003)
