Tetrahedron Letters p. 1677 - 1680 (1997)
Update date:2022-07-30
Topics:
Sloan, Milton J.
Kirk, Kenneth L.
A convenient synthesis of 2-fluoro-1-aminocyclopropane-1-carboxylic acid is described. Cyclopropanation of ethyl 2-(3,4-dimethoxyphenyl)-3-fluoroacrylate followed by Curtius rearrangement, oxidative cleavage of the aromatic ring, and deprotection, produced the α-amino acid.
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