The synthesis and activity of spiroindane growth hormone secretagogues

DOI: 10.1016/S0960-894X(97)00075-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 663 - 668 (1997)

Update date:2022-07-30

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Authors:

Tata, James R.

Nargund, Ravi P.

Murphy, Marcia M.

Johnston, David B. R.

Patchett, Arthur A.

Cheng, Kang

Wei, Liente

Chan, Wanda W.-S.

Butler, Bridget

Jacks, Thomas M.

Hickey, Gerard

Smith, Roy

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Article abstract of DOI:10.1016/S0960-894X(97)00075-9

The synthesis and activities of a series of spiroindane growth hormone secretagogues is reported. Modification of the benzylic position of the spiroindane has resulted in a dramatic increase in potency resulting in subnanomolar peptidomimetic growth hormone secretagogues. In vivo data demonstrating the good oral activity of these analogs is reported.

Full text of DOI:10.1016/S0960-894X(97)00075-9

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