Bioorganic and Medicinal Chemistry Letters p. 663 - 668 (1997)
Update date:2022-07-30
Topics:
Tata, James R.
Nargund, Ravi P.
Murphy, Marcia M.
Johnston, David B. R.
Patchett, Arthur A.
Cheng, Kang
Wei, Liente
Chan, Wanda W.-S.
Butler, Bridget
Jacks, Thomas M.
Hickey, Gerard
Smith, Roy
The synthesis and activities of a series of spiroindane growth hormone secretagogues is reported. Modification of the benzylic position of the spiroindane has resulted in a dramatic increase in potency resulting in subnanomolar peptidomimetic growth hormone secretagogues. In vivo data demonstrating the good oral activity of these analogs is reported.
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