Bioorganic and Medicinal Chemistry Letters p. 663 - 668 (1997)
Update date:2022-07-30
Topics:
Tata, James R.
Nargund, Ravi P.
Murphy, Marcia M.
Johnston, David B. R.
Patchett, Arthur A.
Cheng, Kang
Wei, Liente
Chan, Wanda W.-S.
Butler, Bridget
Jacks, Thomas M.
Hickey, Gerard
Smith, Roy
The synthesis and activities of a series of spiroindane growth hormone secretagogues is reported. Modification of the benzylic position of the spiroindane has resulted in a dramatic increase in potency resulting in subnanomolar peptidomimetic growth hormone secretagogues. In vivo data demonstrating the good oral activity of these analogs is reported.
View Morewebsite:http://www.simagchem.com
Contact:+86-592-2680277
Address:21/F Hualong Office Building,No.6 Hubin East Road, Xiamen,China
Contact:021-50278900
Address:No.6,Room 201 ,Lane 299,bisheng road ,shanghai ,china
Shanghai Taibao Pharmaceutical Technology Co., Ltd(expird)
Contact:021-52217366
Address:shanghai
Nanjing Raise Pharmatech Co., Ltd
website:http://www.raisechem.com
Contact:+86-25-58649566
Address:B381,No.606,Ningliu Road,Jiangbei New Area,Nanjing,Jiangsu Province,China
Contact:+86-571-86217390
Address:No.567 Dengcai Street,Sandun,Westlake District,Hangzhou310030,Zhejiang,China.
Doi:10.1021/ja01856a032
(1941)Doi:10.1021/jo962371x
(1997)Doi:10.1515/znb-1999-0517
(1999)Doi:10.1016/S0040-4039(97)00966-0
(1997)Doi:10.1016/S0008-6215(97)00032-3
(1997)Doi:10.1021/jo01018a035
(1965)
