Synthesis of 5'-C-hydroxyalkylthymidines and their incorporation into oligodeoxynucleotides

Article abstract of DOI:10.1016/S0040-4039(97)00386-9

5'-C-Hydroxymethyl-, 5'-C-hydroxyethyl, and 5'-C-hydroxypropylthymidine derivatives were prepared through four synthetic routes, which constitute an approach to introduce hydroxyalkyl of different lengths at C5' of thymidine. 5'-C-hydroxymethyl- and 5'-C-hydroxypropylthymidines were converted to the corresponding phosphoramidites and incorporated into oligodeoxynucleotides.