Electrochemical removal of the picolinoyl group under mild acidic conditions, application to the protection of amines in peptide synthesis

DOI: 10.1016/S0040-4039(97)00362-6

Source and publish data:

Tetrahedron Letters p. 2283 - 2286 (1997)

Update date:2022-08-05

Topics: Isolation and Purification Peptide Synthesis Monitoring Conditions Electrolysis Electrochemical Deprotection Apparatus

Authors:

Auzeil, Nicolas

Dutruc-Rosset, Gilles

Largeron, Martine

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Article abstract of DOI:10.1016/S0040-4039(97)00362-6

The picolinoyl group can be used as a convenient protective group for amines in peptide chemistry. Deprotection is performed by electrochemical reduction under mild acidic conditions.

Full text of DOI:10.1016/S0040-4039(97)00362-6

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