A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors

DOI: 10.1016/S0960-894X(99)00559-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3181 - 3186 (1999)

Update date:2022-08-05

Topics:

Authors:

Li, Chun-Sing

Black, W. Cameron

Brideau, Christine

Chan, Chi Chung

Charleson, Stella

Cromlish, Wanda A.

Claveau, David

Yves Gauthier, Jacques

Gordon, Robert

Greig, Gillian

Grimm, Erich

Guay, Jocelyne

Lau, Cheuk K.

Riendeau, Denis

Therien, Michel

Visco, Denise M.

Wong, Elizabeth

Xu, Lijing

Prasit, Petpiboon

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Article abstract of DOI:10.1016/S0960-894X(99)00559-4

By inserting an oxygen link between the 3-fluorophenyl and the lactone ring of 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methanesulfonylphenyl)-2(5H)-furanone 1 (DFU), analogs with enhanced in vitro COX-2 inhibitory potency as well as in vivo potency in models of inflammation were obtained.

Full text of DOI:10.1016/S0960-894X(99)00559-4

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