Bioorganic and Medicinal Chemistry Letters p. 3181 - 3186 (1999)
Update date:2022-08-05
Topics:
Li, Chun-Sing
Black, W. Cameron
Brideau, Christine
Chan, Chi Chung
Charleson, Stella
Cromlish, Wanda A.
Claveau, David
Yves Gauthier, Jacques
Gordon, Robert
Greig, Gillian
Grimm, Erich
Guay, Jocelyne
Lau, Cheuk K.
Riendeau, Denis
Therien, Michel
Visco, Denise M.
Wong, Elizabeth
Xu, Lijing
Prasit, Petpiboon
By inserting an oxygen link between the 3-fluorophenyl and the lactone ring of 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methanesulfonylphenyl)-2(5H)-furanone 1 (DFU), analogs with enhanced in vitro COX-2 inhibitory potency as well as in vivo potency in models of inflammation were obtained.
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