A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors

DOI: 10.1016/S0960-894X(99)00559-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3181 - 3186 (1999)

Update date:2022-08-05

Topics:

Authors:

Li, Chun-Sing

Black, W. Cameron

Brideau, Christine

Chan, Chi Chung

Charleson, Stella

Cromlish, Wanda A.

Claveau, David

Yves Gauthier, Jacques

Gordon, Robert

Greig, Gillian

Grimm, Erich

Guay, Jocelyne

Lau, Cheuk K.

Riendeau, Denis

Therien, Michel

Visco, Denise M.

Wong, Elizabeth

Xu, Lijing

Prasit, Petpiboon

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00559-4

By inserting an oxygen link between the 3-fluorophenyl and the lactone ring of 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methanesulfonylphenyl)-2(5H)-furanone 1 (DFU), analogs with enhanced in vitro COX-2 inhibitory potency as well as in vivo potency in models of inflammation were obtained.

Full text of DOI:10.1016/S0960-894X(99)00559-4

Products guided by the article

Product name:2-(2.4-Difluorophenoxy)acetic acid 2-methyl-1-(4-(methylsulfonyl) phenyl)propan-1-one-2-yl ester

Cas No:189955-77-9

R&D Labs maybe for 189955-77-9

WUHU HUAHAI BIOLOGY ENGINEERING CO LTD

Contact:+86-553-3836920

Address:7/F NO.82 LAODONG ROAD WUHU CHINA
Tianjin Te-An Chemtech Co., Ltd.(expird)

Contact:+86-22-65378638

Address:A5-8, No.80 Haiyun Street, TEDA
Sigma-Aldrich Chemie GmbH

website:http://www.sigmaaldrich.com

Contact:800 558-9160

Address:Industriestrasse 25CH-9471 Buchs SGSwitzerland
Suzhou Credit International Trading Co., Ltd

Contact:+86-512-65398039

Address:Qingdeng, Hightech. District, Suzhou
Suqian Ruixing Chemical Co., Ltd.

Contact:+86-527-80805666（总机）;84836008(销售)

Address:3 Jingsilu, Zone north, Hubin Xincheng Development Park, Suqian, China

Relevant to this article

ACYLATION OF 2-AMINO-5-PHENYL-4-OXAZOLINONE AND 2-AMINO-4-IMIDAZOLINONES

Doi:10.1007/BF00514453
(1983)
Synthesis of nickel phenyl complexes with new chelating κ²-P,N ligands derived from α-iminoazatriphenylphosphoranes

Doi:10.1016/S0022-328X(98)00759-1
(1999)
Synthesis of 5-Alkyl-1-aryl-4,4-dimethyl-2,6,7-trioxa as a chemiluminescent substrate with remarkable thermal stability

Doi:10.1016/S0040-4039(97)00483-8
(1997)
Nickel-Catalyzed Facile [2+2+2] Cyclotrimerization of Unactivated Internal Alkynes to Polysubstituted Benzenes

Doi:10.1002/asia.201601469
(2017)
Iridium and rhodium perfluorobenzenethiolato complexes. Syntheses and catalytic behavior

Doi:10.1016/S0020-1693(96)05364-9
(1997)
An NHC-Stabilised Phosphinidene for Catalytic Formylation: A DFT-Guided Approach

Doi:10.1002/chem.202101202
(2021)

Article Doi