2-(tert-Butyldimethylsiloxy)thiophene: Application to total syntheses of both enantiomers of 2',3'-dideoxy-4'-thiocytidine

DOI: 10.1016/0040-4039(95)00162-6

Source and publish data:

Tetrahedron Letters p. 1941 - 1944 (1995)

Update date:2022-08-05

Topics: Deprotection and final steps

Authors:

Rassu Rassu

Spanu Spanu

Pinna Pinna

Zanardi Zanardi

Casiraghi

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Article abstract of DOI:10.1016/0040-4039(95)00162-6

Exploiting novel 2-(tert-butyldimethylsiloxy)thiophene (1, TBSOT) as versatile carbon nucleophile and both enantiomers of glyceraldehyde acetonide as chiral sources, an entry to both enantiomers of anti HIV-active 2',3'-dideoxy-4'-thiocytidine 10 and ent-10 was devised and executed.

Full text of DOI:10.1016/0040-4039(95)00162-6

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