Synthesis and 5α-reductase inhibitory activities of benzofuran derivatives with a carbamoyl group

Article abstract of DOI:10.1016/S0960-894X(98)00001-8

A series of 2-phenylbenzofuran derivatives with a diphenylmethylcarbamoyl group at the 5 or 6 position of the benzofuran ring were synthesized and evaluated for rat and human testosterone 5α-reductase inhibitory activities in vitro. They had inhibitory activities against both enzymes and the 6-carbamoyl derivatives tended to be more potent than the 5-carbamoyl compounds.