Bioorganic and Medicinal Chemistry Letters p. 561 - 566 (1998)
Update date:2022-08-03
Topics:
Ishibashi, Koki
Nakajima, Katsuyoshi
Sugioka, Yuki
Sugiyama, Mitsuo
Hamada, Takakazu
Horikoshi, Hiroyoshi
Nishi, Takahide
A series of 2-phenylbenzofuran derivatives with a diphenylmethylcarbamoyl group at the 5 or 6 position of the benzofuran ring were synthesized and evaluated for rat and human testosterone 5α-reductase inhibitory activities in vitro. They had inhibitory activities against both enzymes and the 6-carbamoyl derivatives tended to be more potent than the 5-carbamoyl compounds.
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