Reaction of α-hydroxyamino ketones with dicarbonyl compounds - Synthesis of imidazoline nitroxides with a functional group in a side chain

Article abstract of DOI:10.1002/jlac.199719970537

The reaction of α-hydroxyamino ketones 1 with diacetyl, acetyl acetone or acetoacetic ester in the presence of ammonium acetate results in the formation of 3-imidazoline derivatives 2, which are precursors for the synthesis of stable nitroxides 8, 9, 14, 16, 17, 23-24 with various functional groups in the side chain at the 2-position of the heterocycle. VCH Verlagsgesellschaft mbH, 1997.