Welcome to LookChem.com Sign In|Join Free

Article Doi

Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases

DOI: 10.1002/cmdc.201500131

Source and publish data:

ChemMedChem p. 1163 - 1173 (2015)

Update date:2022-08-03

Topics:

Authors:

Vonnussbaum, FranzVonnussbaum, Franz

Li, Volkhart M.-J.Li, Volkhart M.-J.

Allerheiligen, SwenAllerheiligen, Swen

Anlauf, SonjaAnlauf, Sonja

B?rfacker, LarsB?rfacker, Lars

Bechem, MartinBechem, Martin

Delbeck, MartinaDelbeck, Martina

Fitzgerald, Mary F.Fitzgerald, Mary F.

Gerisch, MichaelGerisch, Michael

Gielen-Haertwig, HeikeGielen-Haertwig, Heike

Haning, HelmutHaning, Helmut

Karthaus, DagmarKarthaus, Dagmar

Lang, DieterLang, Dieter

Lustig, KlemensLustig, Klemens

Meibom, DanielMeibom, Daniel

Mittendorf, JoachimMittendorf, Joachim

Rosentreter, UlrichRosentreter, Ulrich

Sch?fer, MartinaSch?fer, Martina

Sch?fer, StefanSch?fer, Stefan

Schamberger, JensSchamberger, Jens

Telan, Leila A.Telan, Leila A.

Tersteegen, AdrianTersteegen, Adrian

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1002/cmdc.201500131

Human neutrophil elastase (HNE) is a key protease for matrix degradation. High HNE activity is observed in inflammatory diseases. Accordingly, HNE is a potential target for the treatment of pulmonary diseases such as chronic obstructive pulmonary disease

View More

Full text of DOI:10.1002/cmdc.201500131

Products guided by the article

Product name:3-Penten-2-one, 4-[[3-(trifluoromethyl)phenyl]amino]-

Cas No:191089-75-5

191089-75-5

R&D Labs maybe for 191089-75-5

Relevant to this article

Hot Product