Synthesis of 1-[ω-[(arylamino)carbonyl]alkyl]-4-(benzocycloalkyl)piperazines

DOI: 10.3987/com-97-7736

Source and publish data:

Heterocycles p. 723 - 734 (1997)

Update date:2022-08-03

Topics:

Authors:

El-Ahmad, Youssef

Maillet, Philippe

Laurent, Elisabeth

Talab, Akram

Tran, Gilles

Ollivier, Roland

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Article abstract of DOI:10.3987/com-97-7736

A series of 1-[co-[(arylamino)carbonyl]alkyl]-4-(benzocycloalkyl)-piperazines (1a-v) was prepared either by reacting the precursor 4-[ω-[(arylamino)carbonyl]alkyl]piperazine (2a-j) with 1-chlorobenzocycloalkanes (3a-c) (Procedure A) or by reacting the N-aryl-ω-chloroalkanamides (5a-j) with the 4-(benzocycloalkyl)piperazines (10a-c) (Procedure B). The best yields were obtained using procedure A.

Full text of DOI:10.3987/com-97-7736

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