Bioactive isoxazoline and grime derivatives from 7-ketolignans

Article abstract of DOI:10.1016/S0040-4020(97)00310-4

A new type of cyclolignans with an isoxazoline ring fused to the cyclolignan core has been prepared from 7-ketolignanolides by reaction with hydroxylamine. The corresponding 7-oxime derivatives have also been obtained. The compounds prepared have been evaluated for their cytotoxic activities over four cell lines.