Tetrahedron p. 8447 - 8456 (1997)
Update date:2022-08-02
Topics:
Freville, Stephanie
Bonin, Martine
Celerier, Jean-Peirre
Husson, Henri-Philippe
Lhommet, Gerard
Quirion, Jean-Charles
Thuy, Vu Moc
(+) aid (-) trans-2,6-dimethylpiperidines 9 have been prepared from diastereomeric lactams 6 and 11, both available from (R)-(-)-phenylglycinol 4. Diastereoselective C-2 alkylation afforded oxazolidines 7 and 12. Reduction of 7 with LiAlH4 or NaBH4 led to trans-2,6-8 with total retention of configuration. When 12 was reduced with NaBH4, trans derivative 13a was isolated as the major isomer. A mechanism is proposed to explain the different results.
View MoreDongguan Albiya Energy Science and Technology Co.,Ltd
Contact:+86-769-22181286
Address:Huanan Industial Park, Dongguan,China
ShangHai BMG Chemical Co., Ltd
Contact:+86-13524845543
Address:Room 602, no 291 sikai road shanghai
Shanghai Korey Pharm Co.,Ltd.(expird)
Contact:021-61840961 021-61840962
Address:No.157,Zhuguang Rd, Qingpu, Shanghai, China
Shanghai Coupling Pharmaceutical R&D Co., Ltd.(expird)
Contact:+86 021 50106671
Address:403 Room No.4 Buiding, No. 526 Ruiqing Road, Shanghai Zhangjiang Hi-Tech Park
Chengdu Green Young Biopharmaceutical INC
Contact:+86-28-85337952
Address:1-B-26,Tianhe Industry Park, No.1480 of Tianfu Road,Chengdu,P.R.China,610000
Doi:10.1016/S0277-5387(97)00026-0
(1997)Doi:10.1055/s-2007-983774
(2007)Doi:10.1039/a802306i
(1998)Doi:10.1016/j.jfluchem.2007.01.003
(2007)Doi:10.1021/ja01562a067
(1957)Doi:10.1007/BF02219320
(1996)