Biological and Pharmaceutical Bulletin p. 646 - 650 (1997)
Update date:2022-08-03
Topics:
Saeki, Ken-Ichi
Kawai, Hiroshi
Kawazoe, Yutaka
Hakura, Atsushi
Nineteen mono- and di-fluorinated derivatives of quinoline, 1,7- phenanthroline, 1,10-phenanthroline, benzo-[h]quinoline, and benzo[f]quinoline were subjected to analysis of their structure-mutagenicity relationships. For this purpose, six new fluorinated derivatives were synthesized. The results support that the enamine epoxide structure of the pyridine moiety, as well as the bay-region epoxide structure, is responsible for mutagenicity. Formation of K-region epoxides might involve a detoxification process rather than mutagenic activation.
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()Doi:10.1016/S0040-4020(97)00624-8
(1997)
