Synthesis of γ-lactone derivatives as a key intermediate for the spiroketal fragment in calyculin A

Article abstract of DOI:10.1016/S0040-4020(97)00624-8

A simple and safe route to the D-xylone-l,4-lactone derivative 3, a key intermediate for the synthesis of the spiroketal fragment in calyculin A (I) has been explored without the use of hazardous diazomethane on a large scale.