The synthesis of α-fluoroketones by 1,4-additions of mono-fluorinated enamines to Michael acceptors

DOI: 10.1016/S0022-1139(96)03535-X

Source and publish data:

Journal of Fluorine Chemistry p. 21 - 24 (1997)

Update date:2022-08-03

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Authors:

Bridge, Colin F.

O'Hagan, David

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Article abstract of DOI:10.1016/S0022-1139(96)03535-X

Stork enamine reactions are explored with mono-fluorinated enamines derived from α-fluoroacetophenones and pyrrolidine. The resulting enamines react under mild conditions with Michael acceptors (acrylonitrile, methyl acrylate, methyl methacrylate, methyl vinyl ketone and cyclohexenone) to generate a variety of substituted α-fluoroketones.

Full text of DOI:10.1016/S0022-1139(96)03535-X

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