A practical synthesis of enantiopure ethyl cis-2-amino-1-cyclohexanecarboxylate via asymmetric reductive amination methodology

DOI: 10.1016/S0957-4166(97)00160-2

Source and publish data:

Tetrahedron Asymmetry p. 1445 - 1451 (1997)

Update date:2022-08-03

Topics:

Authors:

Xu, Daqiang

Prasad, Kapa

Repic, Oljan

Blacklock, Thomas J.

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Article abstract of DOI:10.1016/S0957-4166(97)00160-2

A simple and practical method for large scale preparation of optically pure ethyl 2-amino-1-cyclohexanecarboxylate was developed via a reductive amination of 2-oxo-cyclohexanecarboxylate with a chiral α-methylbenzylamine. The major diastereomer was isolat

Full text of DOI:10.1016/S0957-4166(97)00160-2

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Product name:(1S,2R)-2-((S)-1-Phenyl-ethylamino)-cyclohexanecarboxylic acid ethyl ester

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