Synthesis of the naphthoic acid component of kedarcidin chromophore by routes employing photochemical and thermal electrocyclic ring closure reactions.

Article abstract of DOI:10.1016/S0040-4039(97)00844-7

Two different synthetic routes to the naphthoic acid component of kedarcidin chromophore were developed featuring photochemical and thermal electrocyclic ring closure reactions, respectively, as the key step. X-ray crystallographic analysis of the synthetic naphthoic acid confirmed its structure and comparison of ¹H and ¹³C NMR data from its methylamide derivative with those reported for kedarcidin chromophore correspond closely, suggesting that this component of the natural product is correctly assigned.