Novel frameworks for trifluoromethyl ketone and phosphonate TSA inhibitors of type II PLA2

DOI: 10.1016/S0960-894X(97)00246-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1421 - 1426 (1997)

Update date:2022-09-26

Topics:

Authors:

Garigipati, Ravi S.

Seibel, George

Mayer, Ruth J.

Bolognese, Brian

McCord, Mark

Marshall, Lisa A.

Adams, Jerry L.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)00246-1

Design and synthesis of some TSA inhibitors on novel molecular frameworks is described. This TSA analog design culminates in the preparation of the phosphonate 18.

Full text of DOI:10.1016/S0960-894X(97)00246-1

Products guided by the article

Product name:2-Naphthalenecarboxylic acid, 8-[methoxy(octadecyloxy)phosphinyl]-, methyl ester

Cas No:192525-09-0

R&D Labs maybe for 192525-09-0

Hotechem Shanghai Co., Ltd

Contact:13120882795；+86-21-34621078;+86-021-31122318

Address:Suite 2,No.2715 Longwu Road
Taimai Sanluck Pharmaceutical Co.,Ltd

Contact:86-592-7662921

Address:8D,No.186,Huarong Road,Huli,Xiamen,China
Hubei Lingsheng Pharmaceuticals Co., Ltd.

Contact:+86-0710-3538058

Address:Xiangyang City Xiangcheng Economic Development Zone, Hubei Province
Sichuan Sangao Biochemical Co., Ltd

Contact:+86-28-84874233

Address:19F, Bldg.2, Shudu Center, Tianfu 2nd St., Hi-tech zone, Chengdu 610041, Sichuan Province, China.
Chengda Pharmaceuticals Co., Ltd.

Contact:+86-573-84601188

Address:hengshan Road 5# in Jiashan, zhejiang

Relevant to this article

Expanding applications of copper-based metal-organic frameworks in catalysis: Oxidative C-O coupling by direct C-H activation of ethers over Cu₂(BPDC)₂(BPY) as an efficient heterogeneous catalyst

Doi:10.1016/j.jcat.2013.06.006
(2013)
Opening of cyclopropyl ketones with SmI₂ . Synthesis of spirocyclic and bicyclic ketones by intramolecular trapping of an electrophile

Doi:10.1016/S0040-4020(97)00499-7
(1997)
Ferulic acid-carbazole hybrid compounds: Combination of cholinesterase inhibition, antioxidant and neuroprotection as multifunctional anti-Alzheimer agents

Doi:10.1016/j.bmc.2016.01.010
(2016)
Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P₁)

Doi:10.1021/acs.jmedchem.6b00373
(2016)
Highly E-selective synthesis of α,β-unsaturated amides from N-2- methoxyphenyl aldimines via lithium ynolates

Doi:10.1016/S0040-4039(00)00986-2
(2000)
Silica-supported KHSO₄: An efficient system for activation of aromatic terminal olefins

Doi:10.1055/s-0030-1259041
(2010)

Article Doi