Synthesis and biological evluation of a fluorinated analog of the β-adrenergic blocking agent, metoprolol

DOI: 10.1016/S0960-894X(97)00207-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1273 - 1274 (1997)

Update date:2022-08-05

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Authors:

Iseki, Katsuhiko

Oishi, Satoshi

Sasai, Hiroaki

Shibasaki, Masakatsu

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Article abstract of DOI:10.1016/S0960-894X(97)00207-2

Both enantiomers of a difluorinated metoprolol analog (1) were synthesized in enantiomerically pure form and evaluated as β-adrenergic blocking agents.

Full text of DOI:10.1016/S0960-894X(97)00207-2

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