Synthesis and biological evluation of a fluorinated analog of the β-adrenergic blocking agent, metoprolol

DOI: 10.1016/S0960-894X(97)00207-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1273 - 1274 (1997)

Update date:2022-08-05

Topics:

Authors:

Iseki, Katsuhiko

Oishi, Satoshi

Sasai, Hiroaki

Shibasaki, Masakatsu

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)00207-2

Both enantiomers of a difluorinated metoprolol analog (1) were synthesized in enantiomerically pure form and evaluated as β-adrenergic blocking agents.

Full text of DOI:10.1016/S0960-894X(97)00207-2

Products guided by the article

Product name:Acetic acid, difluoro[4-(2-methoxyethyl)phenoxy]-, ethyl ester

Cas No:192575-80-7

R&D Labs maybe for 192575-80-7

Wuhan Sunrise Pharmaceutical Technology Co., Ltd

Contact:+86-27-83314682

Address:Room 340, New material Industrial base No.17, Gu Tian Five Lu , Qiaokou District, Wuhan , China
Hunan Haili Chemical Industry Co.,Ltd.

Contact:+86-731-85521860

Address:No.251, 2nd Section, Furong Road, Changsha,Hunan,China
Hangzhou utanpharma Co., Ltd

Contact:0571-86821378 ,86820258,56836287,56830923,

Address:Block D ,20F, Tianyuan Building,No.508, Wensan RD, 310013,Hangzhou Zhejiang China
Shanghai AoBo Bio-Pharmaceutical Technology Co., Ltd.

Contact:+86-21-51320130-801, 816

Address:Room 601, No. 1011, Halei Road, Zhangjiang High-Tech Park, Pudong, Shanghai
Shaanxi HuaTai Bio-fine chemical company Ltd

Contact:86-029-87862197

Address:No. 5, 3rd Floor, 29 Yanta North Road, Beilin Dist.

Relevant to this article

Temperature-dependent Ring-Opening and -Closure of a Cyclic Phosphane-Borane

Doi:10.1002/cber.19971300722
(1997)
Preparation and cleavage reactions of 3′-thiouridylyl-(3′→5′)-uridine

Doi:10.1039/b002155p
(2000)
Doi:10.1021/ja01110a029
(1953)
Stereodependent fusion and fission of vesicles: Calcium binding of synthetic gemini phospholipids containing two phosphate groups

Doi:10.1021/ja962303s
(1997)
Directed electrophilic cyclizations: Efficient methodology for the synthesis of fused polycyclic aromatics

Doi:10.1021/ja9642673
(1997)
Stepwise and concerted solvolytic elimination and substitution reactions: E1 reaction via a primary carbocation

Doi:10.1021/ja970362f
(1997)

Article Doi