N-ω-carbethoxypentyl-4-quinolones: A new class of leukotriene biosynthesis inhibitors

DOI: 10.1002/ardp.19973300404

Source and publish data:

Archiv der Pharmazie p. 100 - 106 (1997)

Update date:2022-08-03

Topics:

Authors:

Desideri, Nicoletta

Sestili, Isabella

Stein, Maria Luisa

Manarini, Stefano

Dell'Elba, Giuseppe

Cerletti, Chiara

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1002/ardp.19973300404

6-[(4-Quinolinyl)oxy]hexanoic acids and the corresponding esters were designed and synthesized as inhibitors of the production of arachidonic acid metabolites. The inhibitory activities were assayed in vitro by evaluation of serum leukotriene B₄ and thromboxane B₂ production. While all 6-[(4- quinolinyl)oxy]hexanoic acids and their esters proved to be inactive, the N- alkyl-4-quinolones, obtained as by-products in their synthesis, were found to be a new class of leukotriene biosynthesis inhibitors.

Full text of DOI:10.1002/ardp.19973300404

Products guided by the article

Product name:Hexanoic acid, 6-[[8-(phenylmethoxy)-4-quinolinyl]oxy]-, ethyl ester

Cas No:192827-30-8

R&D Labs maybe for 192827-30-8

Shanghai Taibao Pharmaceutical Technology Co., Ltd(expird)

Contact:021-52217366

Address:shanghai
Jiaxing Isen Chemical Co.,Ltd

Contact:0086-0573-85287218

Address:Room 301, Unit 2, Building 3, Alley 94, East Renmin Road, Pinghu City, Zhejiang Province, China
Xiamen Goodhealth Pharmchem Co., Ltd.

Contact:0086-592-2097683

Address:404R No.2 54# Minzu Rd., Xiamen, China
Taixing Shenfeng Chemical Co., Ltd.

Contact:+86-523-87117033, 87117666

Address:4# Yinsanlu, Huangqiao town, Taixing, Jiangsu, China.
Yancheng Creator Chemical Co., Ltd

Contact:0086-515-88710008 88710068 88710858 88710868

Address:No.21 Renming Road, Longgang Town, Yandu County,Yancheng City

Relevant to this article

Catalytic enantioselective addition of hydrogen cyanide to benzaldehyde and p-methoxybenzaldehyde using cyclo-His-(αMe)Phe as catalyst

Doi:10.1016/S0957-4166(97)00178-X
(1997)
Convenient access to sterically hindered C₂ chiral 2,2,5,5-tetraphenyltetrahydrofuran-3,4-diols: intramolecular selective 1,4-cyclocondensation of (2R,3R)- and (2S,3S)-1,1,4,4-tetraphenylbutanetetraols

Doi:10.1016/j.tetasy.2009.10.005
(2009)
Structure-activity relationships, kinetics, selectivity, and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells

Doi:10.1039/b508157b
(2005)
Methyl 3,3,3-trifluoropyruvate: An improved procedure starting from hexafluoropropene-1,2-oxide; identification of byproducts

Doi:10.1016/S0022-1139(02)00007-6
(2002)
Tyrosine kinase inhibitors. 14. Structure-activity relationships for methyl-amino-substituted derivatives of 4-[3-bromophenyl)amino]-6- (methylamino)-pyrido[3,4-d]pyrimidine (PD 158780), a potent and specific inhibitor of the tyrosine kinase activity of receptors for the EGF family of growth factors

Doi:10.1021/jm970641d
(1998)
Doi:10.1021/ja01310a036
(1935)

Article Doi