N-ω-carbethoxypentyl-4-quinolones: A new class of leukotriene biosynthesis inhibitors

DOI: 10.1002/ardp.19973300404

Source and publish data:

Archiv der Pharmazie p. 100 - 106 (1997)

Update date:2022-08-03

Topics:

Authors:

Desideri, Nicoletta

Sestili, Isabella

Stein, Maria Luisa

Manarini, Stefano

Dell'Elba, Giuseppe

Cerletti, Chiara

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Article abstract of DOI:10.1002/ardp.19973300404

6-[(4-Quinolinyl)oxy]hexanoic acids and the corresponding esters were designed and synthesized as inhibitors of the production of arachidonic acid metabolites. The inhibitory activities were assayed in vitro by evaluation of serum leukotriene B₄ and thromboxane B₂ production. While all 6-[(4- quinolinyl)oxy]hexanoic acids and their esters proved to be inactive, the N- alkyl-4-quinolones, obtained as by-products in their synthesis, were found to be a new class of leukotriene biosynthesis inhibitors.

Full text of DOI:10.1002/ardp.19973300404

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